Clinical efficacy of launched JAK inhibitors in rheumatoid arthritis

Inhibitors of JAK for the treatment of rheumatoid arthritis: rationale and clinical data

The JAK/ STAT signal transduction pathway is primarily involved in regulating STAT-target gene transcription. Many of the STAT-target genes are those responsible for the synthesis of proinflammatory cytokines, proteins that regulate apoptosis and/or cell survival and genes that control determination of cell fate. The aberrant over production of proinflammatory cytokines, the imbalance between c...

The Jak-STAT pathway in rheumatoid arthritis.

efficacy of fish oil in rheumatoid arthritis

ingestion of fish oil fatty acids (omega - 3 fatty acids ) inhibits the formation of arachidonic acid - derived cytokines and leads to production of compounds with diminished biological activity. beneficial effects of dietary supplementation with fish oil in rheumatoid arthritis have been shown in many controlled trials.methods : 43 patients with active rheumatoid arthritis entered in a prospec...

Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedside.

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial inflammation and joint destruction. However, the combined use of synthetic disease-modifying anti-rheumatic drug (DMARD) such as methotrexate and a biological DMARD targeting tumour necrosis factor (TNF) has revolutionized treatment of RA. Clinical remission is a realistic target to treat and the maintenance of...

Proteinase inhibitors in rheumatoid arthritis.

The concentrations of five normally occurring protease inhibitors in serum and synovial fluid were compared in patients with rheumatoid arthritis, osteoarthrosis, and normal controls. The patients with rheumatoid arthritis showed a significant rise in alpha1-antitrypsin, alpha1-antichymotrypsin, and inter-alpha-trypsin inhibitor (in decreasing order) in serum as well as in synovial fluid. In sy...